Frequently Asked Questions

GLP-1 (glucagon-like peptide-1) receptor agonists are a class of medications originally developed for type 2 diabetes that have proven highly effective for weight loss. They work by mimicking a natural hormone that regulates appetite, helping you feel full faster and longer while also slowing digestion and stabilizing blood sugar levels.

Semaglutide (brand names Wegovy and Ozempic) targets only the GLP-1 receptor, while Tirzepatide (brand names Zepbound and Mounjaro) is a dual-action medication that targets both GLP-1 and GIP receptors. Clinical studies suggest Tirzepatide may produce slightly greater weight loss results, with some patients losing over 20% of their body weight compared to 15% with Semaglutide.

Compounded GLP-1 medications are custom-made versions of Semaglutide created by licensed compounding pharmacies (503A or 503B facilities). They contain the same active ingredient as brand-name medications but are typically more affordable. Compounded versions are legally produced during drug shortages and offer a cost-effective alternative for patients.

Results vary by individual, but clinical trials show average weight loss of 15-20% of body weight over 12-18 months when combined with lifestyle modifications. Some patients experience more significant results, while others may see more modest changes. Factors like starting weight, adherence to medication, diet, and exercise all influence outcomes.

The most common side effects are gastrointestinal and include nausea, vomiting, diarrhea, constipation, and stomach pain. These side effects are typically most pronounced when starting treatment or increasing dosage and often diminish over time. Starting with a low dose and gradually increasing helps minimize these effects.

Generally, GLP-1 medications are prescribed for adults with a BMI of 30 or higher (obesity), or those with a BMI of 27 or higher who have at least one weight-related health condition such as type 2 diabetes, high blood pressure, or high cholesterol. A licensed healthcare provider will evaluate your individual situation during consultation.

GLP-1 medications are not recommended for individuals with a personal or family history of medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). They should also be avoided during pregnancy and breastfeeding. People with a history of pancreatitis or severe gastrointestinal disease should discuss risks with their doctor.

Most GLP-1 medications for weight loss are administered as once-weekly subcutaneous injections (under the skin). The injections are self-administered using a pre-filled pen device and are typically given in the abdomen, thigh, or upper arm. Most providers include detailed instructions and training materials with your first shipment.

GLP-1 medications are typically prescribed as long-term treatments. Studies show that weight regain commonly occurs after discontinuing the medication. Many patients continue treatment indefinitely to maintain their weight loss, though your healthcare provider will work with you to determine the best long-term plan for your situation.

The telehealth process typically involves completing an online health questionnaire, followed by a virtual consultation with a licensed healthcare provider. If approved, your prescription is sent to a pharmacy, and medication is shipped directly to your home. Most providers offer ongoing support and follow-up consultations as part of their programs.

Reputable online GLP-1 providers employ licensed physicians, use accredited pharmacies, and follow proper medical protocols. We only feature providers on our comparison site that meet these criteria. Look for providers that require a thorough health evaluation, offer ongoing medical support, and are transparent about their processes and pricing.

GLP-1 medications require refrigeration and are shipped in temperature-controlled packaging with cold packs to maintain proper storage conditions. Shipments are typically sent via expedited delivery services. Once received, medications should be stored in the refrigerator until use. Most providers use discreet packaging for privacy.

Insurance coverage varies widely. Some plans cover brand-name GLP-1 medications for weight loss, while others only cover them for diabetes. Compounded versions are typically not covered by insurance. Many telehealth providers offer competitive cash-pay pricing that may be more affordable than brand-name medications even with insurance.

Costs vary significantly by provider and medication type. Brand-name Wegovy or Zepbound can cost $1,000+ per month without insurance. Compounded Semaglutide through telehealth providers typically ranges from $200-500 per month including medication and medical supervision. We recommend comparing multiple providers to find the best value for your budget.

Most telehealth providers include the medication, physician consultations, ongoing medical support, injection supplies, and shipping in their monthly pricing. Some providers also include health coaching, mobile apps for tracking, and educational resources. Always verify exactly what is included before signing up to avoid unexpected charges.

Reputable providers are transparent about their pricing. However, some may charge separate fees for initial consultations, lab work, or shipping. We highlight providers with clear, all-inclusive pricing in our comparisons. Always read the fine print and ask about any additional costs before committing to a program.